Jan 20 2013
A biophysical miRNA-mRNA interaction model infers canonical and noncanonical targets.
Posted in Publications, publishedNo Comment
M Khorshid, J Hausser, M Zavolan and E van Nimwegen
A biophysical miRNA-mRNA interaction model infers canonical and noncanonical targets
Nature methods, 2013, 10 (3), 253-255
Abstract
We introduce a biophysical model of miRNA-target interaction and infer its parameters from Argonaute 2 cross-linking and immunoprecipitation data. We show that a substantial fraction of human miRNA target sites are noncanonical and that predicted target-site affinity correlates well with the extent of target destabilization. Our model provides a rigorous biophysical approach to miRNA target identification beyond ad hoc miRNA seed–based methods.
Short URL: https://tinyurl.com/y4k9yujm
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